modelD08AE03
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Phenol | |
| ATC code: | D08AE03 | route: | topical |
| compartments: | 1 | |
| dosage: | 32 | mg |
| volume of distribution: | 0.7 | L |
| clearance: | 0.25 | L/kg/h |
| other parameters in model implementation | ||
Phenol (ATC D08AE03) is an aromatic organic compound with disinfectant and antiseptic properties. Historically used as a topical antiseptic, its use today is largely limited due to toxicity concerns, but it may still be used in some dermatological preparations and as a chemical cauterant for medical and minor surgical procedures. Phenol is not commonly used systemically as a drug in modern clinical practice.
Pharmacokinetics
Estimated pharmacokinetic parameters in adult humans based on toxicological and limited clinical data. No validated published PK model available for humans for the therapeutic use of phenol.
References
Sun, HF, et al., & Li, D (2018). Chemical Peeling with a Modified Phenol Formula for the Treatment of Facial Freckles on Asian Skin. Aesthetic plastic surgery 42(2) 546–552. DOI:10.1007/s00266-017-1048-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/29279953
Thelin, WR, et al., & Zoukhri, D (2012). Effect of topically applied epithelial sodium channel inhibitors on tear production in normal mice and in mice with induced aqueous tear deficiency. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 28(4) 433–438. DOI:10.1089/jop.2011.0157 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22455658
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)