modelD08AE04
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Triclosan | |
| ATC code: | D08AE04 | route: | oral |
| compartments: | 1 | |
| dosage: | 300 | mg |
| volume of distribution: | 1.3 | L |
| clearance: | 1.5 | L/h/kg |
| other parameters in model implementation | ||
Triclosan is a synthetic, broad-spectrum antimicrobial agent that was widely used in personal care products such as soaps, toothpastes, and deodorants for its antibacterial and antifungal properties. Due to safety concerns and regulatory actions, its use has been restricted or banned in several countries, and it is no longer approved as an over-the-counter consumer antiseptic.
Pharmacokinetics
Estimated pharmacokinetic parameters for healthy adult subjects based on available literature and regulatory reports, as there is a lack of published, peer-reviewed compartmental PK model with explicit parameter values for triclosan in humans.
References
Kraivaphan, P, et al., & Triratana, T (2009). Investigation of triclosan retention and dental plaque viability with a triclosan/PVM/MA copolymer mouthrinse in a Thai population. The Southeast Asian journal of tropical medicine and public health 40(4) 840–847. PUBMED:https://pubmed.ncbi.nlm.nih.gov/19842422
Rotroff, DM, et al., & Thomas, RS (2010). Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. Toxicological sciences : an official journal of the Society of Toxicology 117(2) 348–358. DOI:10.1093/toxsci/kfq220 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20639261
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)