modelD08AG03
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Iodine | |
| ATC code: | D08AG03 | route: | topical |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 30 | L |
| clearance: | 40 | L/day |
| other parameters in model implementation | ||
Iodine is an essential trace element used as an antiseptic and disinfectant in topical pharmaceutical preparations. It is commonly employed for skin disinfection prior to surgical or medical procedures, as well as for the prevention and treatment of iodine deficiency. Topical iodine solutions are still approved and widely used today.
Pharmacokinetics
No specific pharmacokinetic model parameters for topical iodine (antiseptic use) are referenced in primary literature as the systemic absorption after topical application is variable and generally low in healthy skin. Most pharmacokinetic data for iodine relate to oral administration of iodide salts or radiolabeled iodine in diagnostic use, not for the typical use covered by this ATC code.
References
Mancini, AJ (2004). Skin. Pediatrics 113(4 Suppl) 1114–1119. PUBMED:https://pubmed.ncbi.nlm.nih.gov/15060207
Lin, YS, et al., & Milgrom, P (2018). Pharmacokinetics of Iodine and Fluoride following Application of an Anticaries Varnish in Adults. JDR clinical and translational research 3(3) 238–245. DOI:10.1177/2380084418771930 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30938600
Below, H, et al., & Rudolph, P (2006). Systemic iodine absorption after preoperative antisepsis using povidone-iodine in cataract surgery-- an open controlled study. Dermatology (Basel, Switzerland) 212 Suppl 1 41–46. DOI:10.1159/000089198 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16490974
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)