modelD08AL30
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Silver | |
| ATC code: | D08AL30 | route: | topical |
| compartments: | 1 | |
| dosage: | 1 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0 | |
| other parameters in model implementation | ||
Silver is a chemical element that has been used historically in medicine for its antimicrobial properties. Systemic use is largely obsolete due to concerns of toxicity. Today, silver is primarily used topically in the form of silver sulfadiazine or silver nitrate for burns and wound dressings. Silver and its compounds are not approved for systemic use in most countries.
Pharmacokinetics
No peer-reviewed publication has been found that reports quantitative pharmacokinetic models or parameters for elemental silver (ATC code D08AL30) in humans. Most use cases are topical, and systemic absorption is negligible or highly variable and not formally characterized.
References
Ellenikiotis, H, et al., & Milgrom, P (2022). Pharmacokinetics of 38 Percent Silver Diamine Fluoride in Children. Pediatric dentistry 44(2) 114–121. PUBMED:https://pubmed.ncbi.nlm.nih.gov/35484770
Chen, KF, et al., & Lin, YS (2020). Silver Diamine Fluoride in Children Using Physiologically Based PK Modeling. Journal of dental research 99(8) 907–913. DOI:10.1177/0022034520917368 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32374712
Walenga, RL, et al., & Roy, P (2024). Use of the Same Model or Modeling Strategy Across Multiple Submissions: Focus on Complex Drug Products. The AAPS journal 26(1) 12–None. DOI:10.1208/s12248-023-00879-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38177638
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)