modelD10AX05
Extends from Pharmacokinetic.Models.PK_2C_enteral.
Information
| name: | Dapsone | |
| ATC code: | D10AX05 | route: | oral |
| compartments: | 2 | |
| dosage: | 100 | mg |
| volume of distribution: | 1.12 | L |
| clearance: | 1.3 | L/h |
| other parameters in model implementation | ||
Dapsone is an antibacterial sulfone drug primarily used for the treatment of leprosy (Hansen's disease), dermatitis herpetiformis, and as a prophylactic treatment for Pneumocystis jirovecii pneumonia in immunocompromised patients. Dapsone is still approved and in use today, especially in combination therapy for leprosy and for certain skin conditions.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult volunteers after a single oral 100 mg dose.
References
Mirochnick, M, et al., & Spector, SA (2001). Population pharmacokinetics of dapsone in children with human immunodeficiency virus infection. Clinical pharmacology and therapeutics 70(1) 24–32. DOI:10.1067/mcp.2001.115891 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11452241
Mirochnick, M, et al., & McNamara, J (1999). Pharmacokinetics of dapsone administered daily and weekly in human immunodeficiency virus-infected children. Antimicrobial agents and chemotherapy 43(11) 2586–2591. DOI:10.1128/AAC.43.11.2586 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10543733
Gatti, G, et al., & Bassetti, D (1995). Pharmacokinetics of dapsone in human immunodeficiency virus-infected children. Antimicrobial agents and chemotherapy 39(5) 1101–1106. DOI:10.1128/AAC.39.5.1101 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7625796
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
| Pharmacolibrary.Types.TransferRate | ka (from PK_2C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_2C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)