modelG01AD03
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | AscorbicAcid | |
| ATC code: | G01AD03 | route: | oral |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 0.6 | L |
| clearance: | 8 | mL/min/kg |
| other parameters in model implementation | ||
Ascorbic acid (vitamin C) is an essential water-soluble vitamin used to prevent and treat scurvy, a condition caused by vitamin C deficiency. It also acts as an antioxidant and is sometimes used topically or as an adjunct for gynecological or other infections. The ATC code G01AD03 designates ascorbic acid for gynecological use, particularly as a vaginal product for pH regulation. While ascorbic acid is widely approved as a vitamin supplement, its use for gynecological applications is less common in modern clinical practice but still available in some regions.
Pharmacokinetics
Pharmacokinetics of ascorbic acid reported in healthy adult volunteers following oral administration.
References
Hornig, D (1981). Metabolism and requirements of ascorbic acid in man. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 60(21) 818–823. PUBMED:https://pubmed.ncbi.nlm.nih.gov/7029735
Calder, PC, et al., & McKay, DL (2025). Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults. Nutrients 17(2) –. DOI:10.3390/nu17020279 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39861409
Hercberg, S, et al., & Galan, P (2001). Iron deficiency in Europe. Public health nutrition 4(2B) 537–545. DOI:10.1079/phn2001139 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11683548
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)