modelG02AD02
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Dinoprostone | |
| ATC code: | G02AD02 | route: | vaginal |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 0.5 | L |
| clearance: | 2.5 | L/min |
| other parameters in model implementation | ||
Dinoprostone is a synthetic prostaglandin E2 (PGE2) analog used primarily for cervical ripening and labor induction in obstetrics. It is also employed in the management of missed abortion or for evacuation of the uterus. Dinoprostone is an approved medication and is still widely used today, administered via vaginal, endocervical, or rectal routes.
Pharmacokinetics
Pharmacokinetic parameters are mainly based on published pharmacokinetic studies performed in healthy nonpregnant and pregnant women, with administration predominantly via vaginal or suppository route.
References
Lyrenäs, S, et al., & Ulmsten, U (2001). In vivo controlled release of PGE2 from a vaginal insert (0.8 mm, 10 mg) during induction of labour. BJOG : an international journal of obstetrics and gynaecology 108(2) 169–178. DOI:10.1111/j.1471-0528.2001.00039.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/11236117
Asbóth, G, et al., & Hertelendy, F (1985). PGE2 binding, synthesis, and distribution in hen oviduct. The American journal of physiology 248(1 Pt 1) E80–E88. DOI:10.1152/ajpendo.1985.248.1.E80 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2857064
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)