modelG03AC08
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Etonogestrel | |
| ATC code: | G03AC08 | route: | subdermal |
| compartments: | 1 | |
| dosage: | 68 | mg |
| volume of distribution: | 201 | L |
| clearance: | 7.5 | L/h |
| other parameters in model implementation | ||
Etonogestrel is a synthetic progestin used as a hormonal contraceptive. It is the active metabolite of desogestrel and is currently marketed as a subdermal implant (Nexplanon/Implanon) for long-term birth control in women. It is approved and widely used for contraception.
Pharmacokinetics
Pharmacokinetic parameters for healthy women aged 18–40 years receiving the etonogestrel subdermal implant (single 68 mg implant, commonly used contraceptive dose).
References
Clure, C, et al., & Lazorwitz, A (2024). Pilot study of a novel, alternative subdermal scapular insertion site for the etonogestrel contraceptive implant. Contraception 135 110442–None. DOI:10.1016/j.contraception.2024.110442 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38552822
Ali, M, et al., & Hubacher, D (2016). Extended use up to 5 years of the etonogestrel-releasing subdermal contraceptive implant: comparison to levonorgestrel-releasing subdermal implant. Human reproduction (Oxford, England) 31(11) 2491–2498. DOI:10.1093/humrep/dew222 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27671673
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)