modelG03BA03_1
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Testosterone_1 | |
| ATC code: | G03BA03_1 | route: | oral |
| compartments: | 1 | |
| dosage: | 80 | mg |
| volume of distribution: | 425 | L |
| clearance: | 16 | L/h |
| other parameters in model implementation | ||
Testosterone is a naturally occurring steroid hormone that plays a key role in the development of male reproductive tissues and secondary sexual characteristics. It is used clinically for testosterone replacement therapy in males with hypogonadism and in certain other endocrine disorders. Testosterone is an approved drug for therapeutic use in many countries.
Pharmacokinetics
Population pharmacokinetic model for healthy males following single oral administration of testosterone undecanoate.
References
Bhat, SZ, & Dobs, AS (2022). Testosterone Replacement Therapy: A Narrative Review with a Focus on New Oral Formulations. TouchREVIEWS in endocrinology 18(2) 133–140. DOI:10.17925/EE.2022.18.2.133 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36694887
Roth, MY, et al., & Amory, JK (2011). Steady-state pharmacokinetics of oral testosterone undecanoate with concomitant inhibition of 5α-reductase by finasteride. International journal of andrology 34(6 Pt 1) 541–547. DOI:10.1111/j.1365-2605.2010.01120.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/20969601
Amory, JK, et al., & Bremner, WJ (2003). Oral testosterone-triglyceride conjugate in rabbits: single-dose pharmacokinetics and comparison with oral testosterone undecanoate. Journal of andrology 24(5) 716–720. DOI:10.1002/j.1939-4640.2003.tb02732.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/12954663
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)