modelG03GA05
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | FollitropinAlfa | |
| ATC code: | G03GA05 | route: | subcutaneous |
| compartments: | 1 | |
| dosage: | 225 | mg |
| volume of distribution: | 8.9 | L |
| clearance: | 0.5 | L/h |
| other parameters in model implementation | ||
Follitropin alfa is a recombinant human follicle-stimulating hormone (FSH) used primarily in assisted reproductive technology (ART) to induce ovulation in women with infertility problems and stimulate spermatogenesis in men. It is approved for use in fertility treatment.
Pharmacokinetics
Pharmacokinetics in healthy female volunteers after subcutaneous administration of a single dose.
References
Hoy, SM (2016). XM17 Follitropin Alfa (Ovaleap(®)): A Review in Reproductive Endocrine Disorders. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 30(4) 379–386. DOI:10.1007/s40259-016-0183-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27342604
Rose, TH, et al., & Ottesen, JT (2016). Characterisation of Population Pharmacokinetics and Endogenous Follicle-Stimulating Hormone (FSH) Levels After Multiple Dosing of a Recombinant Human FSH (FE 999049) in Healthy Women. Drugs in R&D 16(2) 165–172. DOI:10.1007/s40268-016-0126-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/27139012
Abe, Y, & Ozeki, Y (2022). [Pharmacological profile, clinical efficacy, and safety of Follitropin Delta produced by recombinant DNA technology in a human cell line (REKOVELLE. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 157(1) 76–84. DOI:10.1254/fpj.21079 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34980816
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)