modelH01AA01
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Corticotropin | |
| ATC code: | H01AA01 | route: | intramuscular |
| compartments: | 1 | |
| dosage: | 80 | mg |
| volume of distribution: | 0.5 | L |
| clearance: | 0.1 | L/kg/h |
| other parameters in model implementation | ||
Corticotropin, also known as adrenocorticotropic hormone (ACTH), is a polypeptide hormone produced and secreted by the anterior pituitary gland. It stimulates the adrenal cortex to secrete glucocorticoids, mineralocorticoids, and androgens. Corticotropin is used diagnostically to assess adrenal function and therapeutically in certain inflammatory and autoimmune conditions. Its clinical use has declined due to the availability of synthetic corticosteroids, but it is still approved and occasionally used in specific indications such as infantile spasms and multiple sclerosis exacerbations.
Pharmacokinetics
Estimated pharmacokinetic parameters for corticotropin in healthy adult subjects based on available product information and secondary reviews; no direct population PK modeling identified in peer-reviewed publications.
References
Zhang, J, & Rivest, S (1999). Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation. The European journal of neuroscience 11(8) 2651–2668. DOI:10.1046/j.1460-9568.1999.00682.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/10457163
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)