modelH01CB01
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Somatostatin | |
| ATC code: | H01CB01 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 250 | mg |
| volume of distribution: | 13.7 | L |
| clearance: | 8.3 | liter/hour |
| other parameters in model implementation | ||
Somatostatin is a cyclic peptide hormone that inhibits the secretion of several other hormones, such as growth hormone, insulin, and glucagon. It is used therapeutically to control bleeding from esophageal varices and in the management of certain endocrine and gastrointestinal disorders. Due to its very short half-life, somatostatin is generally used only in hospital settings for acute indications. Synthetic analogues (e.g., octreotide) are commonly used instead for chronic therapy.
Pharmacokinetics
Pharmacokinetic parameters are mainly derived from studies in healthy adult volunteers following intravenous infusion.
References
Barakat, A, et al., & Khier, S (2023). Clinical Pharmacokinetics of Radiopharmaceuticals from SPECT/CT Image Acquisition by Contouring in Patients with Gastroenteropancreatic Neuroendocrine Tumors: Lu-177 DOTATATE (Lutathera. European journal of drug metabolism and pharmacokinetics 48(4) 329–339. DOI:10.1007/s13318-023-00829-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37184824
Liu, F, et al., & Yang, Z (2017). . Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 39(6) 1010428317705519–None. DOI:10.1177/1010428317705519 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28618966
Trocóniz, IF, et al., & Obach, R (2009). Population pharmacokinetic analysis of lanreotide Autogel in healthy subjects : evidence for injection interval of up to 2 months. Clinical pharmacokinetics 48(1) 51–62. DOI:10.2165/0003088-200948010-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19071884
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)