modelH01CB02
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Octreotide | |
| ATC code: | H01CB02 | route: | subcutaneous |
| compartments: | 2 | |
| dosage: | 100 | mg |
| volume of distribution: | 13.6 | L |
| clearance: | 0.58 | L/h |
| other parameters in model implementation | ||
Octreotide is a synthetic octapeptide and somatostatin analogue that inhibits the release of several hormones such as growth hormone and insulin. It is used clinically for the management of acromegaly, treatment of severe diarrhea and flushing associated with carcinoid tumors, vasoactive intestinal peptide tumors (VIPomas), and other neuroendocrine tumors. Octreotide is currently approved and in use for these indications.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult volunteers after subcutaneous administration.
References
Glatard, A, et al., & Tiberg, F (2025). Population Pharmacokinetic Analysis of an Octreotide Depot (CAM2029) in the Treatment of Acromegaly. Clinical pharmacokinetics None –. DOI:10.1007/s40262-025-01522-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/40418492
Comets, E, et al., & Vonderscher, J (2003). Population pharmacodynamic analysis of octreotide in acromegalic patients. Clinical pharmacology and therapeutics 73(1) 95–106. DOI:10.1067/mcp.2003.6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12545148
Dogliotti, L, et al., & Fabiani, L (2001). The clinical management of neuroendocrine tumors with long-acting repeatable (LAR) octreotide: comparison with standard subcutaneous octreotide therapy. Annals of oncology : official journal of the European Society for Medical Oncology 12 Suppl 2 S105–S109. DOI:10.1093/annonc/12.suppl_2.s105 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11762334
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)