modelJ01AA07
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Tetracycline | |
| ATC code: | J01AA07 | route: | oral |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 1.3 | L |
| clearance: | 48 | mL/min |
| other parameters in model implementation | ||
Tetracycline is a broad-spectrum antibiotic belonging to the tetracycline class, historically used to treat various bacterial infections such as respiratory tract infections, urinary tract infections, skin infections, and some sexually transmitted infections. While widely used in the past, resistance and newer agents have limited its routine use in some countries, but it remains approved and is still used in specific indications.
Pharmacokinetics
Pharmacokinetics reported in healthy adult volunteers (oral administration).
References
Tao, RE, et al., & Feldman, SR (2023). Oral Tetracycline-Class Drugs in Dermatology: Impact of Food Intake on Absorption and Efficacy. Antibiotics (Basel, Switzerland) 12(7) –. DOI:10.3390/antibiotics12071152 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37508248
Thompson, EJ, et al., & Hornik, CP (2019). Population Pharmacokinetics of Doxycycline in Children. Antimicrobial agents and chemotherapy 63(12) –. DOI:10.1128/AAC.01508-19 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31548185
Rodvold, KA, et al., & Pai, MP (2020). Omadacycline: A Review of the Clinical Pharmacokinetics and Pharmacodynamics. Clinical pharmacokinetics 59(4) 409–425. DOI:10.1007/s40262-019-00843-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31773505
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)