modelJ01CA12
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Piperacillin | |
| ATC code: | J01CA12 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 4000 | mg |
| volume of distribution: | 14.4 | L |
| clearance: | 13.0 | L/h |
| other parameters in model implementation | ||
Piperacillin is a broad-spectrum β-lactam antibiotic of the ureidopenicillin class. It is commonly used, often in combination with the β-lactamase inhibitor tazobactam, for the treatment of a wide variety of bacterial infections, including respiratory tract infections, urinary tract infections, gastrointestinal infections, and sepsis. Piperacillin is approved and widely used in clinical practice today, particularly in hospital settings.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult subjects following intravenous administration.
References
Dhaese, SAM, et al., & De Waele, JJ (2018). Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients. International journal of antimicrobial agents 51(4) 594–600. DOI:10.1016/j.ijantimicag.2017.12.015 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29277531
Alobaid, AS, et al., & Roberts, JA (2017). Population Pharmacokinetics of Piperacillin in Nonobese, Obese, and Morbidly Obese Critically Ill Patients. Antimicrobial agents and chemotherapy 61(3) –. DOI:10.1128/AAC.01276-16 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28052849
Chen, R, et al., & Wang, LY (2016). Population Pharmacokinetics and Pharmacodynamics of Piperacillin/Tazobactam in Patients with Nosocomial Infections. European journal of drug metabolism and pharmacokinetics 41(4) 363–372. DOI:10.1007/s13318-015-0276-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25894901
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)