modelJ01CA17

Extends from Pharmacokinetic.Models.PK_2C.

Information

name:	Temocillin
ATC code:	J01CA17
route:	intravenous
compartments:	2
dosage:	2000	mg
volume of distribution:	12	L
clearance:	4.8	L/h
other parameters in model implementation

Temocillin is a narrow-spectrum, beta-lactamase-resistant penicillin antibiotic. It is primarily used for treating infections caused by Gram-negative bacteria, including Enterobacteriaceae that produce extended-spectrum beta-lactamases (ESBLs). Temocillin is not active against Gram-positive organisms or non-fermenters like Pseudomonas aeruginosa. It is approved in some European countries but is not widely used globally.

Pharmacokinetics

PK parameters were determined in healthy adult volunteers after a single intravenous bolus administration.

References

Ngougni Pokem, P, et al., & Laterre, PF (2022). Population Pharmacokinetics of Temocillin Administered by Continuous Infusion in Patients with Septic Shock Associated with Intra-Abdominal Infection and Ascitic Fluid Effusion. Antibiotics (Basel, Switzerland) 11(7) –. DOI:10.3390/antibiotics11070898 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35884152
De Jongh, R, et al., & Carryn, S (2008). Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection. The Journal of antimicrobial chemotherapy 61(2) 382–388. DOI:10.1093/jac/dkm467 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18070831

Parameters

Type	Name	Default	Description
Modelica.Units.SI.Mass	weight (from PK_1C)	75	patient weight (kg)
Modelica.Units.SI.SpecificVolume	VdPerKg (from PK_1C)	0.9	Volume of distribution (L/kg)
Modelica.Units.SI.MassFraction	F (from PK_1C)	0.8	bioavailiability (0-1)
Pharmacolibrary.Types.Clearance	Cl (from PK_1C)	20	clearance
Modelica.Units.SI.Time	adminTime (from PK_1C)	60	first administration time (s)
Modelica.Units.SI.Time	adminDuration (from PK_1C)	600	administration duration (s)
Modelica.Units.SI.Time	adminPeriod (from PK_1C)	86060	period of administration (default 8 hours)(s)
Pharmacolibrary.Types.Mass	adminMass (from PK_1C)	1000	administration mass (mg)
Integer	adminCount (from PK_1C)	8	number of dose administered (1)
Pharmacolibrary.Types.Volume	Vd (from PK_1C)	VdPerKg*weight	Volume of distribution (m3)
Pharmacolibrary.Types.MassConcentration	Cmin (from PK_1C)	0.004	minimal therapeutic range
Pharmacolibrary.Types.MassConcentration	Cmax (from PK_1C)	0.008	minimal therapeutic range
Pharmacolibrary.Types.MassConcentration	Ctox_peak (from PK_1C)	0.012	toxicity peak level
Pharmacolibrary.Types.MassConcentration	Ctox_trough (from PK_1C)	0.006	toxicity trough level
Pharmacolibrary.Types.Volume	Vdp (from PK_2C)	VdpPerKg*weight	Volume of distribution (m3)
Modelica.Units.SI.SpecificVolume	VdpPerKg (from PK_2C)	0.9	Volume of distribution peripheral(l/kg)
Pharmacolibrary.Types.Clearance	k12 (from PK_2C)	1	intercompartmental C-P clearance
Pharmacolibrary.Types.Clearance	k21 (from PK_2C)	1	intercompartmental P-C clearance

Connectors

Type	Name	Default	Description
Types.ConcentrationOutput	C_central (from PK_1C)
Interfaces.ConcentrationPort_b	centralCPort (from PK_1C)
Interfaces.ConcentrationPort_b	peripheralCPort (from PK_2C)
Pharmacolibrary.Types.ConcentrationOutput	C_peripheral1 (from PK_2C)

Components

Type	Name	Description
Pharmacokinetic.NoPerfusedTissueCompartment	central (from PK_1C)
Pharmacokinetic.ClearanceDrivenElimination	elim (from PK_1C)
Sources.PeriodicDose	periodicDose (from PK_1C)
Modelica.Units.SI.Time	t1_2 (from PK_1C)	elimination half-life
Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym	transfer (from PK_2C)
Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment	peripheral (from PK_2C)

Revisions

06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)