modelJ01CR02
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | AmoxicillinAndBetaLactamaseInhibitor | |
| ATC code: | J01CR02 | route: | oral |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 21.8 | L |
| clearance: | 12.3 | L/h |
| other parameters in model implementation | ||
A combination antibacterial medication consisting of amoxicillin, a broad-spectrum penicillin antibiotic, and a beta-lactamase inhibitor (commonly clavulanic acid), which extends the spectrum of amoxicillin by inhibiting bacterial beta-lactamase enzymes. It is approved and widely used today for the treatment of infections such as respiratory tract infections, urinary tract infections, skin infections, and others caused by susceptible bacteria.
Pharmacokinetics
Pharmacokinetic parameters in healthy adult volunteers after a single oral administration of amoxicillin in combination with clavulanic acid.
References
Mellon, G, et al., & Crémieux, AC (2020). Population pharmacokinetics and dosing simulations of amoxicillin in obese adults receiving co-amoxiclav. The Journal of antimicrobial chemotherapy 75(12) 3611–3618. DOI:10.1093/jac/dkaa368 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32888018
Schouwenburg, S, et al., & Preijers, T (2025). A Pooled Population Pharmacokinetic Study of Oral and Intravenous Administration of Clavulanic Acid in Neonates and Infants: Targeting Effective Beta-Lactamase Inhibition. Clinical pharmacology and therapeutics 117(1) 193–202. DOI:10.1002/cpt.3423 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39205386
de Velde, F, et al., & Mouton, JW (2016). Non-linear absorption pharmacokinetics of amoxicillin: consequences for dosing regimens and clinical breakpoints. The Journal of antimicrobial chemotherapy 71(10) 2909–2917. DOI:10.1093/jac/dkw226 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27330071
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)