modelJ01DC09
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Cefmetazole | |
| ATC code: | J01DC09 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 1000 | mg |
| volume of distribution: | 0.2 | L |
| clearance: | 1.6 | L/h |
| other parameters in model implementation | ||
Cefmetazole is a second-generation cephamycin antibiotic used for the treatment of infections caused by susceptible Gram-positive and Gram-negative bacteria. It is used primarily in Japan and some Asian countries for respiratory, urinary, and intra-abdominal infections, but is not widely approved in the US or EU.
Pharmacokinetics
Pharmacokinetic parameters in healthy adult volunteers after single intravenous administration.
References
Komatsu, T, et al., & Atsuda, K (2022). Timing of re-dosing based on population pharmacokinetic-pharmacodynamics target attainment analysis of cefmetazole in subjects undergoing lower gastrointestinal surgery. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 28(8) 1105–1111. DOI:10.1016/j.jiac.2022.03.024 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35400549
Borin, MT, et al., & Smith, TC (1990). Pharmacokinetics and dose proportionality of cefmetazole in healthy young and elderly volunteers. Antimicrobial agents and chemotherapy 34(10) 1944–1948. DOI:10.1128/AAC.34.10.1944 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2291659
Tomizawa, A, et al., & Atsuda, K (2017). Optimal dosage of cefmetazole for intraoperative antimicrobial prophylaxis in patients undergoing surgery for colorectal cancer. Journal of pharmaceutical health care and sciences 3 1–None. DOI:10.1186/s40780-016-0071-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28074152
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)