modelJ01DD04_1
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Ceftriaxone_1 | |
| ATC code: | J01DD04_1 | route: | intramuscular |
| compartments: | 2 | |
| dosage: | 1000 | mg |
| volume of distribution: | 7.0 | L |
| clearance: | 0.8 | L/h |
| other parameters in model implementation | ||
Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum activity against both gram-positive and gram-negative bacteria. It is widely used for the treatment of infections such as pneumonia, meningitis, gonorrhea, and sepsis. Ceftriaxone is approved for clinical use worldwide and is often administered intravenously or intramuscularly in both hospital and outpatient settings.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult subjects after single intramuscular administration.
References
Unemo, M, et al., & Jacobsson, S (2024). Pharmacodynamic evaluation of ceftriaxone single-dose therapy (0.125-1 g) to eradicate ceftriaxone-susceptible and ceftriaxone-resistant Neisseria gonorrhoeae strains in a hollow fibre infection model for gonorrhoea. The Journal of antimicrobial chemotherapy 79(5) 1006–1013. DOI:10.1093/jac/dkae063 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38497988
Zhou, HH, et al., & Sun, M (1985). Single-dose pharmacokinetics of ceftriaxone in healthy Chinese adults. Antimicrobial agents and chemotherapy 27(2) 192–196. DOI:10.1128/AAC.27.2.192 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3985603
Khan, AM, et al., & Fuchs, GJ (2006). Extended-interval gentamicin administration in malnourished children. Journal of tropical pediatrics 52(3) 179–184. DOI:10.1093/tropej/fmi085 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16126804
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)