modelJ01DD16
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Cefditoren | |
| ATC code: | J01DD16 | route: | oral |
| compartments: | 1 | |
| dosage: | 400 | mg |
| volume of distribution: | 9.3 | L |
| clearance: | 11.6 | L/h |
| other parameters in model implementation | ||
Cefditoren is an orally administered third-generation cephalosporin antibiotic used for the treatment of respiratory tract infections and skin infections caused by susceptible bacteria. It is approved in several countries for adult and pediatric use, especially for community-acquired pneumonia, acute exacerbations of chronic bronchitis, pharyngitis, and uncomplicated skin infections.
Pharmacokinetics
Pharmacokinetic parameters were obtained from studies in healthy adult volunteers after a single oral dose in the fasted state.
References
Matsumoto, K, et al., & Shibasaki, S (2014). Population pharmacokinetics of cefditoren pivoxil in non-infected adults. The Japanese journal of antibiotics 67(1) 49–66. PUBMED:https://pubmed.ncbi.nlm.nih.gov/24809208
Igarashi, Y, et al., & Matsumoto, K (2023). In vivo Pharmacokinetics/Pharmacodynamics Profiles for Appropriate Doses of Cefditoren pivoxil against S. pneumoniae in Murine Lung-Infection Model. Pharmaceutical research 40(7) 1789–1797. DOI:10.1007/s11095-023-03539-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37253866
Matsumoto, K, et al., & Shibasaki, S (2013). Population pharmacokinetic analysis of cefditoren pivoxil in pediatric patients with infection. The Japanese journal of antibiotics 66(6) 357–375. PUBMED:https://pubmed.ncbi.nlm.nih.gov/24649799
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)