modelJ02AX04
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Caspofungin | |
| ATC code: | J02AX04 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 70 | mg |
| volume of distribution: | 9.7 | L |
| clearance: | 0.55 | l/h |
| other parameters in model implementation | ||
Caspofungin is an echinocandin antifungal agent approved for the treatment of invasive aspergillosis in patients who are refractory to or intolerant of other therapies, as well as for empirical therapy for presumed fungal infections in febrile neutropenic patients. It is also used against Candida infections, including candidemia and esophageal candidiasis.
Pharmacokinetics
Pharmacokinetic parameters reported for adult healthy volunteers and patients with invasive fungal infections. Intravenous infusion. Parameters represent typical administration of a 70 mg loading dose followed by 50 mg daily.
References
Borsuk-De Moor, A, et al., & Wiczling, P (2020). Nonstationary Pharmacokinetics of Caspofungin in ICU Patients. Antimicrobial agents and chemotherapy 64(9) –. DOI:10.1128/AAC.00345-20 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32601169
Li, CC, et al., & Stone, JA (2011). Population pharmacokinetics and pharmacodynamics of caspofungin in pediatric patients. Antimicrobial agents and chemotherapy 55(5) 2098–2105. DOI:10.1128/AAC.00905-10 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21300834
Leshinsky, J, et al., & Barrs, VR (2017). Pharmacokinetics of caspofungin acetate to guide optimal dosing in cats. PloS one 12(6) e0178783–None. DOI:10.1371/journal.pone.0178783 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28575121
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)