modelJ05AH03
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Peramivir | |
| ATC code: | J05AH03 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 600 | mg |
| volume of distribution: | 12.56 | L |
| clearance: | 10.1 | L/h |
| other parameters in model implementation | ||
Peramivir is a neuraminidase inhibitor antiviral drug used for the treatment of influenza. It is administered primarily as a single-dose intravenous infusion for adults with acute uncomplicated influenza. Peramivir is approved for use in the United States and several other countries.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult subjects after a single 600 mg intravenous dose.
References
Matsuo, Y, et al., & Wajima, T (2015). Population pharmacokinetics of peramivir in healthy volunteers and influenza patients. Antimicrobial agents and chemotherapy 59(11) 6755–6762. DOI:10.1128/AAC.00799-15 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26282420
Zhang, D, et al., & Liu, H (2015). Pharmacokinetics of peramivir after single intravenous doses in healthy Chinese subjects. Xenobiotica; the fate of foreign compounds in biological systems 45(3) 239–243. DOI:10.3109/00498254.2014.960907 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25231091
Sugaya, N, et al., & Takahashi, T (2012). Efficacy, safety, and pharmacokinetics of intravenous peramivir in children with 2009 pandemic H1N1 influenza A virus infection. Antimicrobial agents and chemotherapy 56(1) 369–377. DOI:10.1128/AAC.00132-11 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22024821
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)