modelL04AX01
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Azathioprine | |
| ATC code: | L04AX01 | route: | oral |
| compartments: | 1 | |
| dosage: | 100 | mg |
| volume of distribution: | 2.0 | L |
| clearance: | 2.2 | L/min |
| other parameters in model implementation | ||
Azathioprine is an immunosuppressive antimetabolite used to prevent organ transplant rejection and to treat autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. It is an approved drug still in clinical use.
Pharmacokinetics
Pharmacokinetic parameters in healthy adult subjects after a single oral dose.
References
Rosenbaum, SE, et al., & Akhlaghi, F (2005). Population pharmacokinetics of cyclosporine in cardiopulmonary transplant recipients. Therapeutic drug monitoring 27(2) 116–122. DOI:10.1097/01.ftd.0000148448.51225.2c PUBMED:https://pubmed.ncbi.nlm.nih.gov/15795639
Ettenger, RB, & Grimm, EM (2001). Safety and efficacy of TOR inhibitors in pediatric renal transplant recipients. American journal of kidney diseases : the official journal of the National Kidney Foundation 38(4 Suppl 2) S22–S28. DOI:10.1053/ajkd.2001.27838 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11583941
Dirks, NL, et al., & Meibohm, B (2004). Pharmacokinetics of immunosuppressants: a perspective on ethnic differences. International journal of clinical pharmacology and therapeutics 42(12) 701–718. DOI:10.5414/cpp42701 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15624287
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)