modelM02AA27
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Dexketoprofen | |
| ATC code: | M02AA27 | route: | oral |
| compartments: | 1 | |
| dosage: | 25 | mg |
| volume of distribution: | 0.25 | L |
| clearance: | 0.19 | L/h/kg |
| other parameters in model implementation | ||
Dexketoprofen is the (S)-enantiomer of ketoprofen, belonging to the non-steroidal anti-inflammatory drug (NSAID) class. It is used for the short-term treatment of mild to moderate acute pain, including musculoskeletal pain and dysmenorrhea. Dexketoprofen is approved for use in several countries.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy male and female volunteers after administration of a single oral dose.
References
Rodríguez, MJ, et al., & Amaro, SR (2008). Dexketoprofen trometamol: clinical evidence supporting its role as a painkiller. Expert review of neurotherapeutics 8(11) 1625–1640. DOI:10.1586/14737175.8.11.1625 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18986233
Valles, J, et al., & Capriati, A (2006). Single and repeated dose pharmacokinetics of dexketoprofen trometamol in young and elderly subjects. Methods and findings in experimental and clinical pharmacology 28 Suppl A 13–19. PUBMED:https://pubmed.ncbi.nlm.nih.gov/16801988
Varrassi, G, et al., & Scarpignato, C (2017). Multimodal analgesia in moderate-to-severe pain: a role for a new fixed combination of dexketoprofen and tramadol. Current medical research and opinion 33(6) 1165–1173. DOI:10.1080/03007995.2017.1310092 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28326850
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)