modelM03AC07

Diagram of M03AC07

Extends from Pharmacokinetic.Models.PK_3C.

Information

name:DoxacuriumChloride
ATC code:M03AC07
route:intravenous
compartments:3
dosage:0.05mg
volume of distribution:0.086L
clearance:1.78ml/min/kg
other parameters in model implementation

Doxacurium chloride is a non-depolarizing neuromuscular blocking agent of the benzylisoquinolinium class. It was primarily used as an adjunct to general anesthesia to facilitate tracheal intubation and provide skeletal muscle relaxation during surgical procedures or mechanical ventilation. Doxacurium is not commonly used today due to the availability of neuromuscular blockers with more favorable profiles.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult surgical patients following single intravenous bolus administration.

References

    Parameters

    TypeNameDefaultDescription
    Modelica.Units.SI.Massweight (from PK_1C)75patient weight (kg)
    Modelica.Units.SI.SpecificVolumeVdPerKg (from PK_1C)0.9Volume of distribution (L/kg)
    Modelica.Units.SI.MassFractionF (from PK_1C)0.8bioavailiability (0-1)
    Pharmacolibrary.Types.ClearanceCl (from PK_1C)20clearance
    Modelica.Units.SI.TimeadminTime (from PK_1C)60first administration time (s)
    Modelica.Units.SI.TimeadminDuration (from PK_1C)600administration duration (s)
    Modelica.Units.SI.TimeadminPeriod (from PK_1C)8*60*60period of administration (default 8 hours)(s)
    Pharmacolibrary.Types.MassadminMass (from PK_1C)1000administration mass (mg)
    IntegeradminCount (from PK_1C)8number of dose administered (1)
    Pharmacolibrary.Types.VolumeVd (from PK_1C)VdPerKg*weightVolume of distribution (m3)
    Pharmacolibrary.Types.MassConcentrationCmin (from PK_1C)0.004minimal therapeutic range
    Pharmacolibrary.Types.MassConcentrationCmax (from PK_1C)0.008minimal therapeutic range
    Pharmacolibrary.Types.MassConcentrationCtox_peak (from PK_1C)0.012toxicity peak level
    Pharmacolibrary.Types.MassConcentrationCtox_trough (from PK_1C)0.006toxicity trough level
    Pharmacolibrary.Types.VolumeVdp (from PK_2C)VdpPerKg*weightVolume of distribution (m3)
    Modelica.Units.SI.SpecificVolumeVdpPerKg (from PK_2C)0.9Volume of distribution peripheral(l/kg)
    Pharmacolibrary.Types.Clearancek12 (from PK_2C)1intercompartmental C-P clearance
    Pharmacolibrary.Types.Clearancek21 (from PK_2C)1intercompartmental P-C clearance
    Pharmacolibrary.Types.VolumeVdp2 (from PK_3C)Vdp2PerKg*weightVolume of distribution (m3)
    Modelica.Units.SI.SpecificVolumeVdp2PerKg (from PK_3C)0.9Volume of distribution peripheral 2 (l/kg)
    Pharmacolibrary.Types.VolumeFlowRatek13 (from PK_3C)1intercompartmental 1-3 clearance (l/min)
    Pharmacolibrary.Types.VolumeFlowRatek31 (from PK_3C)1intercompartmental 3-1 clearance (l/min)

    Connectors

    TypeNameDefaultDescription
    Types.ConcentrationOutputC_central (from PK_1C)
    Interfaces.ConcentrationPort_bcentralCPort (from PK_1C)
    Interfaces.ConcentrationPort_bperipheralCPort (from PK_2C)
    Pharmacolibrary.Types.ConcentrationOutputC_peripheral1 (from PK_2C)
    Interfaces.ConcentrationPort_bperihperal2Cport (from PK_3C)
    Pharmacolibrary.Types.ConcentrationOutputC_peripheral2 (from PK_3C)

    Components

    TypeNameDefaultDescription
    Pharmacokinetic.NoPerfusedTissueCompartmentcentral (from PK_1C)
    Pharmacokinetic.ClearanceDrivenEliminationelim (from PK_1C)
    Sources.PeriodicDoseperiodicDose (from PK_1C)
    Modelica.Units.SI.Timet1_2 (from PK_1C)elimination half-life
    Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSymtransfer (from PK_2C)
    Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartmentperipheral (from PK_2C)
    Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartmentperipheral1 (from PK_3C)
    Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSymtransfer1 (from PK_3C)

    Revisions

    • 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)