modelM03BX01
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Baclofen | |
| ATC code: | M03BX01 | route: | oral |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 0.8 | L |
| clearance: | 180 | ml/min |
| other parameters in model implementation | ||
Baclofen is a centrally acting skeletal muscle relaxant primarily used to treat spasticity due to multiple sclerosis, spinal cord injury, or other neurological conditions. It acts as a GABA-B receptor agonist and is an approved medication in many countries for the management of muscle spasticity.
Pharmacokinetics
Pharmacokinetic parameters in healthy adult subjects after single oral baclofen dose administration.
References
Chevillard, L, et al., & Declèves, X (2018). Population pharmacokinetics of oral baclofen at steady-state in alcoholic-dependent adult patients. Fundamental & clinical pharmacology 32(2) 239–248. DOI:10.1111/fcp.12330 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29091319
He, Y, et al., & Jusko, WJ (2014). Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy. The Journal of pediatrics 164(5) 1181–1188.e8. DOI:10.1016/j.jpeds.2014.01.029 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24607242
Wiersma, HE, et al., & Benninga, MA (2003). Pharmacokinetics of a single oral dose of baclofen in pediatric patients with gastroesophageal reflux disease. Therapeutic drug monitoring 25(1) 93–98. DOI:10.1097/00007691-200302000-00014 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12548151
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)