modelM05BX05
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Burosumab | |
| ATC code: | M05BX05 | route: | subcutaneous |
| compartments: | 1 | |
| dosage: | 1 | mg |
| volume of distribution: | 8.0 | L |
| clearance: | 0.29 | L/day |
| other parameters in model implementation | ||
Burosumab is a fully human monoclonal antibody targeting fibroblast growth factor 23 (FGF23). It is used for the treatment of X-linked hypophosphatemia (XLH) in adults and children 1 year of age and older. It is an approved drug for this indication in the US and EU.
Pharmacokinetics
Pharmacokinetic parameters reported for adult and pediatric patients with X-linked hypophosphatemia following subcutaneous administration. Based on population PK analysis.
References
Lee, SK, et al., & Shi, J (2022). Population Pharmacokinetics and Pharmacodynamics of Burosumab in Adult and Pediatric Patients With X-linked Hypophosphatemia. Journal of clinical pharmacology 62(1) 87–98. DOI:10.1002/jcph.1950 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34352114
Zhang, X, et al., & Carpenter, TO (2016). Population pharmacokinetic and pharmacodynamic analyses from a 4-month intradose escalation and its subsequent 12-month dose titration studies for a human monoclonal anti-FGF23 antibody (KRN23) in adults with X-linked hypophosphatemia. Journal of clinical pharmacology 56(4) 429–438. DOI:10.1002/jcph.611 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26247790
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)