modelN01AB05
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Trichloroethylene | |
| ATC code: | N01AB05 | route: | inhalation |
| compartments: | 2 | |
| dosage: | 450 | mg |
| volume of distribution: | 0.67 | L |
| clearance: | 1.4 | mL/min/kg |
| other parameters in model implementation | ||
Trichloroethylene is a volatile chlorinated organic solvent that has been used historically as an inhalation anesthetic and analgesic agent but is now primarily employed in industrial applications as a degreasing solvent. Due to concerns about toxicity, carcinogenicity, and safer alternatives, medical use in anesthesia has been discontinued in most countries.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult human volunteers following single inhalation exposure.
References
Waters, EM, et al., & Huff, JE (1977). Trichloroethylene. I. An overview. Journal of toxicology and environmental health 2(3) 671–707. DOI:10.1080/15287397709529469 PUBMED:https://pubmed.ncbi.nlm.nih.gov/403297
Rouhou, MC, et al., & Haddad, S (2015). In vivo effects of naproxen, salicylic acid, and valproic acid on the pharmacokinetics of trichloroethylene and metabolites in rats. Journal of toxicology and environmental health. Part A 78(11) 671–684. DOI:10.1080/15287394.2015.1020977 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26039745
Sohn, MD, et al., & Blancato, JN (2004). Reconstructing population exposures from dose biomarkers: inhalation of trichloroethylene (TCE) as a case study. Journal of exposure analysis and environmental epidemiology 14(3) 204–213. DOI:10.1038/sj.jea.7500314 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15141149
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)