modelN01AF03
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Thiopental | |
| ATC code: | N01AF03 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 250 | mg |
| volume of distribution: | 2.7 | L |
| clearance: | 190 | ml/min |
| other parameters in model implementation | ||
Thiopental (formerly marketed as sodium thiopental, known as Pentothal) is a rapid-onset short-acting barbiturate anesthetic. It was widely used for induction of anesthesia and for short surgical or diagnostic procedures. It is no longer widely available or used in many countries today, but remains of historical and pharmacological significance.
Pharmacokinetics
Parameters reported for healthy adult subjects after single intravenous bolus administration.
References
Stanski, DR, & Maitre, PO (1990). Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited. Anesthesiology 72(3) 412–422. DOI:10.1097/00000542-199003000-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2310020
Huynh, F, et al., & Ensom, MH (2009). A critical review: does thiopental continuous infusion warrant therapeutic drug monitoring in the critical care population?. Therapeutic drug monitoring 31(2) 153–169. DOI:10.1097/FTD.0b013e318196fb9f PUBMED:https://pubmed.ncbi.nlm.nih.gov/19177032
Eilers, H, & Niemann, C (2003). Clinically important drug interactions with intravenous anaesthetics in older patients. Drugs & aging 20(13) 969–980. DOI:10.2165/00002512-200320130-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14561101
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)