modelN01AX07
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Etomidate | |
| ATC code: | N01AX07 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 20 | mg |
| volume of distribution: | 2.2 | L |
| clearance: | 15.6 | mL/min/kg |
| other parameters in model implementation | ||
Etomidate is a short-acting intravenous anesthetic agent used for the induction of general anesthesia and sedation for short procedures. It is known for its rapid onset and minimal cardiovascular effects, making it particularly useful in patients with hemodynamic instability. It is approved and clinically used for anesthesia induction.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult subjects after intravenous bolus administration.
References
Lin, L, et al., & Zhang, MZ (2012). Population pharmacokinetics of intravenous bolus etomidate in children over 6 months of age. Paediatric anaesthesia 22(4) 318–326. DOI:10.1111/j.1460-9592.2011.03696.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/21917057
Su, F, et al., & Drover, DR (2015). Population pharmacokinetics of etomidate in neonates and infants with congenital heart disease. Biopharmaceutics & drug disposition 36(2) 104–114. DOI:10.1002/bdd.1924 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25377074
Kaneda, K, et al., & Han, TH (2011). Population pharmacokinetics and pharmacodynamics of brief etomidate infusion in healthy volunteers. Journal of clinical pharmacology 51(4) 482–491. DOI:10.1177/0091270010369242 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20498288
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)