modelN01AX11
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | SodiumOxybate | |
| ATC code: | N01AX11 | route: | oral |
| compartments: | 1 | |
| dosage: | 4500 | mg |
| volume of distribution: | 0.2 | L |
| clearance: | 8.15 | mL/min/kg |
| other parameters in model implementation | ||
Sodium oxybate is the sodium salt of gamma-hydroxybutyric acid (GHB), a central nervous system depressant primarily used in the treatment of narcolepsy, particularly for cataplexy and excessive daytime sleepiness. It is approved for medical use as an orphan drug in several countries, including the US and EU.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult volunteers after oral administration of sodium oxybate.
References
Chen, C, et al., & Plazzi, G (2020). Population and Noncompartmental Pharmacokinetics of Sodium Oxybate Support Weight-Based Dosing in Children and Adolescents With Narcolepsy With Cataplexy. Clinical and translational science 13(5) 932–940. DOI:10.1111/cts.12780 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32216084
Schep, LJ, et al., & Mégarbane, B (2012). The clinical toxicology of γ-hydroxybutyrate, γ-butyrolactone and 1,4-butanediol. Clinical toxicology (Philadelphia, Pa.) 50(6) 458–470. DOI:10.3109/15563650.2012.702218 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22746383
Fung, HL, et al., & Mi Fung, S (2008). Pharmacokinetics of 1,4-butanediol in rats: bioactivation to gamma-hydroxybutyric acid, interaction with ethanol, and oral bioavailability. The AAPS journal 10(1) 56–69. DOI:10.1208/s12248-007-9006-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18446506
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)