modelN01BC01
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Cocaine | |
| ATC code: | N01BC01 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 32 | mg |
| volume of distribution: | 2.7 | L |
| clearance: | 2.3 | L/min |
| other parameters in model implementation | ||
Cocaine is a tropane alkaloid and potent central nervous system stimulant, primarily known as a recreational drug with strong stimulant properties as well as a local anesthetic. Historically used in medicine for local anesthesia (especially in ophthalmic and oral/nasal surgery), it is now rarely used therapeutically due to its high abuse potential and is a controlled substance.
Pharmacokinetics
Pharmacokinetic parameters for cocaine after intravenous administration in healthy adult male volunteers (n=6), as reported in a two-compartment model.
References
Rook, EJ, et al., & Beijnen, JH (2006). Population pharmacokinetics of heroin and its major metabolites. Clinical pharmacokinetics 45(4) 401–417. DOI:10.2165/00003088-200645040-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16584286
van Amsterdam, J, & van den Brink, W (2025). Explaining the high mortality among opioid-cocaine co-users compared to opioid-only users. A systematic review. Journal of addictive diseases 43(2) 121–131. DOI:10.1080/10550887.2024.2331522 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38504419
Fattinger, K, et al., & Verotta, D (2000). Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine. European journal of clinical pharmacology 56(4) 305–310. DOI:10.1007/s002280000147 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10954344
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)