modelN02AC04
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Dextropropoxyphene | |
| ATC code: | N02AC04 | route: | oral |
| compartments: | 1 | |
| dosage: | 65 | mg |
| volume of distribution: | 16 | L |
| clearance: | 7.5 | L/h/kg |
| other parameters in model implementation | ||
Dextropropoxyphene is a mild opioid analgesic formerly used for the management of mild to moderate pain. It was also available in combination with other drugs such as paracetamol for pain relief. Due to concerns about toxicity, risk of overdose, and cardiac side effects, dextropropoxyphene has been withdrawn or banned in many countries and is no longer widely approved for medical use.
Pharmacokinetics
Reported pharmacokinetics in healthy adult volunteers following a single oral dose.
References
Murphy, EJ (2005). Acute pain management pharmacology for the patient with concurrent renal or hepatic disease. Anaesthesia and intensive care 33(3) 311–322. DOI:10.1177/0310057X0503300306 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15973913
Wilson, JT, et al., & Shand, DG (1976). Disposition of propoxyphene and propranolol in children. Clinical pharmacology and therapeutics 19(3) 264–270. DOI:10.1002/cpt1976193264 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1261164
Yin, OQ, et al., & Chow, MS (2010). CYP3A5 but not CYP2D6 polymorphism contributes significantly to the variability in dextropropoxyphene disposition. Journal of clinical pharmacology 50(10) 1136–1141. DOI:10.1177/0091270009359006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20133509
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)