modelN02AE01_1
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Buprenorphine_1 | |
| ATC code: | N02AE01_1 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 0.3 | mg |
| volume of distribution: | 188 | L |
| clearance: | 51 | L/h |
| other parameters in model implementation | ||
Buprenorphine is a semi-synthetic opioid used primarily for pain management and opioid dependence therapy. It acts as a partial agonist at mu-opioid receptors, providing analgesia and mitigating opioid withdrawal symptoms.
Pharmacokinetics
Pharmacokinetics after intravenous administration in healthy adults.
References
Hakomäki, H, et al., & Kokki, M (2021). Pharmacokinetics of buprenorphine in pregnant sheep after intravenous injection. Pharmacology research & perspectives 9(2) e00726–None. DOI:10.1002/prp2.726 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33619904
Jensen, ML, et al., & Christrup, L (2007). Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers. European journal of clinical pharmacology 63(12) 1153–1159. DOI:10.1007/s00228-007-0377-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17874319
Pypendop, BH, et al., & Barter, LS (2023). Pharmacokinetics of buprenorphine and its metabolite norbuprenorphine in neutered male cats anesthetized with isoflurane. Veterinary anaesthesia and analgesia 50(4) 349–355. DOI:10.1016/j.vaa.2023.04.004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37270407
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)