modelN02AJ18
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | OxycodoneAndAcetylsalicylicAcid | |
| ATC code: | N02AJ18 | route: | oral |
| compartments: | 1 | |
| dosage: | 5 | mg |
| volume of distribution: | 2.5 | L |
| clearance: | 20 | L/h |
| other parameters in model implementation | ||
Oxycodone and acetylsalicylic acid is a combination analgesic product used for the treatment of moderate to severe pain. Oxycodone is a semi-synthetic opioid analgesic, while acetylsalicylic acid (aspirin) is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. This fixed-dose combination is used to provide synergistic pain relief. Combination preparations of oxycodone and acetylsalicylic acid have been available in some countries but are not widely used or approved today due to the availability of safer alternatives and regulatory concerns around opioid use.
Pharmacokinetics
Estimated pharmacokinetic parameters for healthy adult subjects, based on the separate pharmacokinetics of oxycodone and acetylsalicylic acid administered orally as a fixed-dose combination.
References
Murphy, EJ (2005). Acute pain management pharmacology for the patient with concurrent renal or hepatic disease. Anaesthesia and intensive care 33(3) 311–322. DOI:10.1177/0310057X0503300306 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15973913
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)