modelN03AB52
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | PhenytoinCombinations | |
| ATC code: | N03AB52 | route: | oral |
| compartments: | 1 | |
| dosage: | 300 | mg |
| volume of distribution: | 0.65 | L |
| clearance: | 0.013 | L/kg/h |
| other parameters in model implementation | ||
Phenytoin is an antiepileptic drug primarily used for the prevention and control of seizures, especially in the treatment of generalized tonic-clonic (grand mal) and complex partial seizures. Combinations of phenytoin with other drugs (ATC N03AB52) are sometimes used when polytherapy is needed for seizure control. Phenytoin is currently approved and widely used in clinical practice.
Pharmacokinetics
Pharmacokinetic parameters estimated for a typical adult patient (age 18-65 years) with epilepsy taking phenytoin combination therapy, based on average data reported for phenytoin oral administration. No specific published population PK data available for phenytoin combinations under ATC N03AB52; estimates based on standard adult data for phenytoin monotherapy.
References
Li, ZD, et al., & Huang, YA (2016). Population Pharmacokinetics of Phenytoin Based on NONMEM in Patients with Intracranial Tumor During the First Week of Post-Craniotomy. Current drug metabolism 17(7) 721–728. DOI:10.2174/1389200217666160513132716 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27174459
Mungall, DR, et al., & Crawford, MH (1985). Population pharmacokinetics of racemic warfarin in adult patients. Journal of pharmacokinetics and biopharmaceutics 13(3) 213–227. DOI:10.1007/BF01065653 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3841364
Graves, NM, et al., & Leppik, IE (1998). Population pharmacokinetics of carbamazepine in adults with epilepsy. Pharmacotherapy 18(2) 273–281. PUBMED:https://pubmed.ncbi.nlm.nih.gov/9545146
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)