modelN03AF01
Extends from Pharmacokinetic.Models.PK_2C_enteral.
Information
| name: | Carbamazepine | |
| ATC code: | N03AF01 | route: | oral |
| compartments: | 2 | |
| dosage: | 400 | mg |
| volume of distribution: | 0.8 | L |
| clearance: | 2.13 | L/h |
| other parameters in model implementation | ||
Carbamazepine is an anticonvulsant and mood-stabilizing drug primarily used for the treatment of epilepsy and neuropathic pain, as well as bipolar disorder. It is an approved medication used worldwide for controlling certain types of seizures, trigeminal neuralgia, and as an adjunct in the management of psychiatric disorders.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult volunteers following single oral dosing.
References
Djordjevic, N, et al., & Milovanovic, JR (2017). Pharmacokinetics and Pharmacogenetics of Carbamazepine in Children. European journal of drug metabolism and pharmacokinetics 42(5) 729–744. DOI:10.1007/s13318-016-0397-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28064419
El Desoky, ES, et al., & Derendorf, H (2012). Population pharmacokinetics of steady-state carbamazepine in Egyptian epilepsy patients. Journal of clinical pharmacy and therapeutics 37(3) 352–355. DOI:10.1111/j.1365-2710.2011.01296.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/21883329
Elewa, M, et al., & Matar, K (2023). Population Pharmacokinetics of Topiramate in Patients with Epilepsy Using Nonparametric Modeling. Therapeutic drug monitoring 45(6) 797–804. DOI:10.1097/FTD.0000000000001143 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37798835
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
| Pharmacolibrary.Types.TransferRate | ka (from PK_2C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_2C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)