modelN06AG02
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Moclobemide | |
| ATC code: | N06AG02 | route: | oral |
| compartments: | 1 | |
| dosage: | 150 | mg |
| volume of distribution: | 1.0 | L |
| clearance: | 20 | L/h |
| other parameters in model implementation | ||
Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA) used primarily as an antidepressant for the treatment of major depressive disorder and social phobia. It is approved in some countries for these indications, though not in the United States.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult volunteers, both sexes, aged 18-65 years, after single oral dose.
References
Fuseau, E, et al., & Ibbotson, T (2002). Clinical pharmacokinetics of intranasal sumatriptan. Clinical pharmacokinetics 41(11) 801–811. DOI:10.2165/00003088-200241110-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12190330
Schoerlin, MP, & Guentert, TW (1989). [Pharmacokinetics and metabolism of reversible MAO-A inhibitors in the human]. Psychiatrische Praxis 16 Suppl 1 11–17. PUBMED:https://pubmed.ncbi.nlm.nih.gov/2685852
Holford, NH, et al., & Banken, L (1994). Monoamine oxidase-A: pharmacodynamics in humans of moclobemide, a reversible and selective inhibitor. British journal of clinical pharmacology 37(5) 433–439. DOI:10.1111/j.1365-2125.1994.tb05710.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/7519866
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)