modelN06BA09
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Atomoxetine | |
| ATC code: | N06BA09 | route: | oral |
| compartments: | 1 | |
| dosage: | 40 | mg |
| volume of distribution: | 0.85 | L |
| clearance: | 22 | L/h |
| other parameters in model implementation | ||
Atomoxetine is a selective norepinephrine reuptake inhibitor used primarily for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children, adolescents, and adults. It is a non-stimulant medication and is approved by regulatory agencies for the treatment of ADHD.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult volunteers after single oral administration.
References
Sauer, JM, et al., & Witcher, JW (2005). Clinical pharmacokinetics of atomoxetine. Clinical pharmacokinetics 44(6) 571–590. DOI:10.2165/00003088-200544060-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15910008
Chalon, SA, et al., & Horsmans, Y (2003). Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites. Clinical pharmacology and therapeutics 73(3) 178–191. DOI:10.1067/mcp.2003.25 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12621383
De Hondt, L, et al., & Tommelein, E (2024). Quantification of ADHD medication in biological fluids of pregnant and breastfeeding women with liquid chromatography: a comprehensive review. Frontiers in public health 12 1437328–None. DOI:10.3389/fpubh.2024.1437328 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39171321
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)