modelS01AA23
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Netilmicin | |
| ATC code: | S01AA23 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 150 | mg |
| volume of distribution: | 0.25 | L |
| clearance: | 80 | ml/min |
| other parameters in model implementation | ||
Netilmicin is a semisynthetic aminoglycoside antibiotic derived from sisomicin. It is used to treat serious bacterial infections, particularly those caused by Gram-negative bacteria, and is typically reserved for use when other aminoglycosides may not be effective due to resistance. It is primarily administered parenterally due to poor absorption orally. While it has been clinically used in the past, current use is limited due to concerns about nephrotoxicity and ototoxicity, and safer alternatives being available.
Pharmacokinetics
Pharmacokinetic parameters reported for adults with normal renal function following intravenous administration.
References
Jauregizar, N, et al., & Calvo, R (2003). Population pharmacokinetics of netilmicin in short-term prophylactic treatment. British journal of clinical pharmacology 55(6) 552–559. DOI:10.1046/j.1365-2125.2003.01783.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/12814449
Tréluyer, JM, et al., & Pons, G (2000). Population pharmacokinetic analysis of netilmicin in neonates and infants with use of a nonparametric method. Clinical pharmacology and therapeutics 67(6) 600–609. DOI:10.1067/mcp.2000.106695 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10872642
Sherwin, CM, et al., & Reith, DM (2008). Individualising netilmicin dosing in neonates. European journal of clinical pharmacology 64(12) 1201–1208. DOI:10.1007/s00228-008-0536-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18685839
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)