modelS01AD05
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Interferon | |
| ATC code: | S01AD05 | route: | ocular |
| compartments: | 1 | |
| dosage: | 1 | mg |
| volume of distribution: | 0.2 | L |
| clearance: | 0.01 | L/kg/h |
| other parameters in model implementation | ||
Interferons are a group of signaling proteins produced and released by host cells in response to the presence of various pathogens, such as viruses, bacteria, or tumor cells. Interferon alfa is used therapeutically for the treatment of various conditions including viral infections (such as hepatitis B and C), certain cancers, and multiple sclerosis. Formulations with ocular use (ATC S01AD05) are indicated for certain eye diseases, but as of now, they are not widely used or approved for routine ophthalmic practice.
Pharmacokinetics
Estimated pharmacokinetic parameters for interferon in an ophthalmic (ocular) application; limited or no published peer-reviewed clinical PK data available for ATC code S01AD05. Parameters below are generalized estimates or extrapolations from systemic use.
References
Ang, M, et al., & Chee, SP (2012). Interferon-gamma release assay as a diagnostic test for tuberculosis-associated uveitis. Eye (London, England) 26(5) 658–665. DOI:10.1038/eye.2012.1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22302066
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)