modelS01AE03_1
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Ciprofloxacin_1 | |
| ATC code: | S01AE03_1 | route: | ophthalmic |
| compartments: | 1 | |
| dosage: | 0.3 | mg |
| volume of distribution: | 0.46 | L |
| clearance: | 0.029 | L/h |
| other parameters in model implementation | ||
Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat a variety of bacterial infections, including urinary tract infections, respiratory tract infections, and eye infections. It is approved for both systemic and ophthalmic uses in many countries.
Pharmacokinetics
One-compartment model following topical ophthalmic administration (eye drops) in healthy subjects.
References
Morlet, N, et al., & Lam, CM (2000). Pharmacokinetics of ciprofloxacin in the human eye: a clinical study and population pharmacokinetic analysis. Antimicrobial agents and chemotherapy 44(6) 1674–1679. DOI:10.1128/AAC.44.6.1674-1679.2000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10817727
Hendrix, DV, et al., & Cox, SK (2007). Pharmacokinetics of topically applied ciprofloxacin in equine tears. Veterinary ophthalmology 10(6) 344–347. DOI:10.1111/j.1463-5224.2007.00566.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/17970994
Di Marco, MP, et al., & Ducharme, MP (2004). A population pharmacokinetic-metabolism model for individualizing ciprofloxacin therapy in ophthalmology. Therapeutic drug monitoring 26(4) 401–407. DOI:10.1097/00007691-200408000-00010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15257070
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)