modelS01AE08
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Besifloxacin | |
| ATC code: | S01AE08 | route: | ophthalmic |
| compartments: | 1 | |
| dosage: | 1 | mg |
| volume of distribution: | 0.12 | L |
| clearance: | 0.08 | L/h/kg |
| other parameters in model implementation | ||
Besifloxacin is a fourth-generation fluoroquinolone antibiotic primarily used as an ophthalmic solution for the treatment of bacterial conjunctivitis. It is approved for topical ocular use and is known for its broad-spectrum antibacterial activity against gram-positive and gram-negative pathogens.
Pharmacokinetics
Pharmacokinetic parameters following topical ocular administration in healthy adults; limited systemic absorption due to administration route.
References
Chang, MH, & Fung, HB (2010). Besifloxacin: a topical fluoroquinolone for the treatment of bacterial conjunctivitis. Clinical therapeutics 32(3) 454–471. DOI:10.1016/j.clinthera.2010.03.013 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20399984
Segreti, J, et al., & Bertino, JS (2012). Challenges in assessing microbial susceptibility and predicting clinical response to newer-generation fluoroquinolones. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 28(1) 3–11. DOI:10.1089/jop.2011.0072 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21999341
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)