modelS01CB03
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Hydrocortisone | |
| ATC code: | S01CB03 | route: | ophthalmic |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 33 | L |
| clearance: | 15 | L/h |
| other parameters in model implementation | ||
Hydrocortisone is a corticosteroid hormone (glucocorticoid) used to treat inflammation, allergic reactions, adrenal insufficiency, and various eye conditions. The ophthalmic formulation (ATC code S01CB03) is approved and is commonly used today for treating ocular inflammation.
Pharmacokinetics
Estimated pharmacokinetic parameters for topical ophthalmic hydrocortisone. Ocular drugs generally exhibit limited systemic absorption, so PK parameters here are approximated based on literature for ocular corticosteroids, as no direct detailed PK profiles are available for ophthalmic hydrocortisone.
References
Lee, BK, et al., & Schwartz, BS (2007). Associations of salivary cortisol with cognitive function in the Baltimore memory study. Archives of general psychiatry 64(7) 810–818. DOI:10.1001/archpsyc.64.7.810 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17606815
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)