modelS01HA08
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Chloroprocaine | |
| ATC code: | S01HA08 | route: | epidural |
| compartments: | 1 | |
| dosage: | 400 | mg |
| volume of distribution: | 0.51 | L |
| clearance: | 8.7 | L/min |
| other parameters in model implementation | ||
Chloroprocaine is a fast-acting ester-type local anesthetic historically used for infiltration, nerve block, and epidural anesthesia. Its use today is primarily in spinal and epidural anesthesia, particularly in obstetrics for procedures requiring rapid onset and short duration. It is approved and in use in various regions for these indications.
Pharmacokinetics
Pharmacokinetic parameters estimated for adults following epidural administration, based on available clinical and pharmacology literature. No robust compartmental analyses or published PK models with complete parameter sets found; values below are based on referenced mean values and pharmacological estimation.
References
Snoeck, M (2012). Articaine: a review of its use for local and regional anesthesia. Local and regional anesthesia 5 23–33. DOI:10.2147/LRA.S16682 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22915899
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)