modelS01JA01
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Fluorescein | |
| ATC code: | S01JA01 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 500 | mg |
| volume of distribution: | 0.5 | L |
| clearance: | 1.11 | L/h/kg |
| other parameters in model implementation | ||
Fluorescein is a synthetic organic compound used primarily as a diagnostic dye in ophthalmology for the assessment of corneal abrasions, vascular disorders, and to visualize blood vessels in the eye. It is approved for clinical use and is widely used today both topically and intravenously for retinal angiography.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult volunteers following intravenous bolus administration.
References
Rizk, DV, et al., & Molitoris, BA (2018). A Novel Method for Rapid Bedside Measurement of GFR. Journal of the American Society of Nephrology : JASN 29(6) 1609–1613. DOI:10.1681/ASN.2018020160 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29748326
Thorling, CA, et al., & Roberts, MS (2015). Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition. Drug metabolism and disposition: the biological fate of chemicals 43(1) 154–162. DOI:10.1124/dmd.114.060848 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25380806
Sim, DA, et al., & Fruttiger, M (2015). A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocyanine green dye. Disease models & mechanisms 8(11) 1479–1487. DOI:10.1242/dmm.019018 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26398933
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)