modelS01XA10
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Inosine | |
| ATC code: | S01XA10 | route: | oral |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 30 | L |
| clearance: | 12 | L/h |
| other parameters in model implementation | ||
Inosine is a purine nucleoside that forms when hypoxanthine is attached to a ribose ring via a β-N9-glycosidic bond. It has been investigated for several indications, including ophthalmic use as a cytoprotective and metabolic enhancer (mainly in Eastern Europe and Russia), and as an adjunct in neurology (such as in multiple sclerosis and Parkinson's disease investigational studies). Inosine is not approved for widespread therapeutic use in most countries but may be used in some as a supportive or off-label medication.
Pharmacokinetics
No formal published pharmacokinetic (PK) parameters are available for inosine in humans or in published ophthalmic studies; estimates are provided based on analogous nucleoside compounds and general pharmacokinetic principles.
References
Staatz, CE, & Tett, SE (2007). Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients. Clinical pharmacokinetics 46(1) 13–58. DOI:10.2165/00003088-200746010-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17201457
Li, H, et al., & McCune, JS (2014). Pharmacokinetic and pharmacodynamic analysis of inosine monophosphate dehydrogenase activity in hematopoietic cell transplantation recipients treated with mycophenolate mofetil. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20(8) 1121–1129. DOI:10.1016/j.bbmt.2014.03.032 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24727337
McHutchison, JG, et al., & Alam, J (2005). A randomized, double-blind, placebo-controlled dose-escalation trial of merimepodib (VX-497) and interferon-alpha in previously untreated patients with chronic hepatitis C. Antiviral therapy 10(5) 635–643. PUBMED:https://pubmed.ncbi.nlm.nih.gov/16152757
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)