modelS01XA15
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | AscorbicAcid | |
| ATC code: | S01XA15 | route: | ophthalmic |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 0.2 | L |
| clearance: | 0.01 | L/h |
| other parameters in model implementation | ||
Ascorbic acid, also known as vitamin C, is an essential nutrient involved in tissue repair, enzymatic production of certain neurotransmitters, and immune function. It acts as an antioxidant and is used to prevent and treat vitamin C deficiency, including scurvy. Ascorbic acid ophthalmic, corresponding to ATC code S01XA15, is used topically in the eye for aiding corneal healing and reducing oxidative stress. It is approved for clinical use in many regions.
Pharmacokinetics
Pharmacokinetic parameters estimated for topical ophthalmic administration in adults; limited published PK data specific to ophthalmic use.
References
Kim, M, et al., & Jung, H (2014). Novel cosmetic patches for wrinkle improvement: retinyl retinoate- and ascorbic acid-loaded dissolving microneedles. International journal of cosmetic science 36(3) 207–212. DOI:10.1111/ics.12115 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24910870
Johnson, EJ, et al., & Lang, JC (2014). Bioavailability of AREDS1 micronutrients from softgel capsules and tablets: a pilot study. Molecular vision 20 1228–1242. PUBMED:https://pubmed.ncbi.nlm.nih.gov/25352732
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)