modelS01XA26
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Riboflavin | |
| ATC code: | S01XA26 | route: | ocular |
| compartments: | 1 | |
| dosage: | 0.3 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0.05 | L/h |
| other parameters in model implementation | ||
Riboflavin, also known as vitamin B2, is an essential water-soluble vitamin involved in energy metabolism in all living cells. It is used as a dietary supplement, in the treatment of riboflavin deficiency, and for prophylaxis of migraine headaches. For ophthalmic use (ATC code S01XA26), riboflavin is utilized as a photosensitizer in corneal collagen cross-linking procedures primarily for keratoconus. It is approved for these uses.
Pharmacokinetics
Estimated pharmacokinetic parameters for riboflavin, as specific peer-reviewed PK values for the ophthalmic ATC code S01XA26 use are not reported in published literature. Parameters based on general properties and estimated ocular bioavailability.
References
Price, MO, et al., & Price, FW (2018). Prospective Randomized Trial of Corneal Cross-linking Riboflavin Dosing Frequencies for Treatment of Keratoconus and Corneal Ectasia. Ophthalmology 125(4) 505–511. DOI:10.1016/j.ophtha.2017.10.034 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29203068
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)