modelS03AA02
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Tetracycline | |
| ATC code: | S03AA02 | route: | oral |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 1.3 | L |
| clearance: | 37 | mL/min |
| other parameters in model implementation | ||
Tetracycline is a broad-spectrum antibiotic from the tetracycline class that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It has been widely used for the treatment of various bacterial infections including respiratory tract infections, urinary tract infections, skin infections, and certain sexually transmitted diseases. While it is still used today, resistance has limited its application in some settings.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult volunteers after a single oral dose.
References
Tao, RE, et al., & Feldman, SR (2023). Oral Tetracycline-Class Drugs in Dermatology: Impact of Food Intake on Absorption and Efficacy. Antibiotics (Basel, Switzerland) 12(7) –. DOI:10.3390/antibiotics12071152 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37508248
Thompson, EJ, et al., & Hornik, CP (2019). Population Pharmacokinetics of Doxycycline in Children. Antimicrobial agents and chemotherapy 63(12) –. DOI:10.1128/AAC.01508-19 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31548185
Rodvold, KA, et al., & Pai, MP (2020). Omadacycline: A Review of the Clinical Pharmacokinetics and Pharmacodynamics. Clinical pharmacokinetics 59(4) 409–425. DOI:10.1007/s40262-019-00843-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31773505
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)